Heparin

 

Class:
Anticoagulant.


Actions:
Functions as an anticoagulant by accelerating neutralization of activated clotting factors.


Indications:
Situations where a hypocoaguable state is required (i.e. post MI, post-CVA, pulmonary embolism).


Contraindications:
Should not be used unless there is a medical reason to anticoagulate the patient.


Precautions:
Fever, urticaria, and anaphylaxis have been reported following heparin administration skin necrosis can develop at site of subQ injections.


Side Effects:
Fever, bruising, oozing of blood.


Dosage:
Loading dose: 5,000 iu IV is a typical loading dose although large patients and patients with heparin resistance may receive larger doses.


Maintenance dose:
Infusion therapy is typically started at 800 - 1,000 iu/hour. the dosage is modified based upon the patient's prothrombin (pt) time.


Routes:
IV subQ (for prophylaxis).


Pediatric Dosage:
Rarely used.

 

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