Sections
Trandate (Normodyne, Labetalol)
Class:
Sympathetic blocker.
Actions:
Selectively blocks ÿ1 receptors and non selectively blocks ß receptors.
Indications:
Hypertensive crisis.
Contraindications:
Bronchial asthma
Congestive heart failure
Heart block
Bradycardia
Cardiogenic shock.
Precautions:
Blood pressure, pulse, and EKG must be constantly monitored. Atropine and transcutaneous pacing should be available.
Side Effects:
Bradycardia, heart block, congestive heart failure, bronchospasm, postural hypotension.
Dosage:
Method 1: 20 mg by slow IV infusion over 2 minutes; doses of 40 mg can be repeated in 10 minutes until desired supine blood pressure is obtained or until 300 mg of the drug has been given.
Method 2: 200 mg placed in 500 ml d5w to deliver 2 mg/minute.
Routes:
IV infusion or slow IV bolus as described earlier.
Pediatric Dosage:
Safety in children has not been established
